A similar argument could be proposed for VCAN: the hypomethylation in depressed individuals of the present sample somehow resembles the decreased gene expression in an animal model of depression proposed by Pajer et al.43 Note that current results for both VCAN and WDR26 are consistent with those proposed by Pajer et al.43 Likewise, Lee et al.46 reported downregulation of RPL3 hippocampal gene expression in an animal model of stress, in agreement with the current DNA methylation finding. Here, VCAN is linked to major depressive disorder.