ZNF423 and Joubert syndrome: Protocadherin encodes a family of proteins that are expressed in neurons and are relevant in synaptic functions, and whose DNA methylation may be altered in response to early-life stress;60, 61, 62, 63 the ZNF423 gene has been associated with the cerebellum-related Joubert syndrome.64 Also, the dopamine transporter gene SLC6A3, whose DNA sequence and methylation levels have been found to correlate with depressive psychopathology,65, 66, 67 was within the enriched pathways (Table 3).