Constant activation of NF-κB in cancer cells is linked to high production of inflammatory mediators such as tumor necrosis factor (TNF), interleukin-1 (IL-1), IL-6, prostaglandin E2 (PGE2), and reactive oxygen species (ROS) within the tumor microenvironment [3,75,76]. The gene discussed is NFKB1; the disease is cancer.