↓ Tumor growth↑ Bax/Bcl-2 ratio ↑ PARP cleavage ↑ Caspase-3, -9 expression ↓ NF-κB activity ↓ PPAR-γ expression ↓ PSA, IGF-1 serum levels. The gene discussed is NFKB1; the disease is neoplasm.