CASP3 and familial pancreatic carcinoma: By inhibiting the STAT3-mediated pathway, EGCG blocked the migration and invasive capacity of the pancreatic cancer cell lines AsPC-1 and PANC-1 in vitro. In both cell lines, EGCG induced apoptosis by up-regulating caspase-3 activity and enhancing gemcitabine-induced cleavage of caspase-3 and PARP.