TRIP13 and cancer: Intriguingly, human TRIP13 has also been identified as an oncogene: TRIP13 is overexpressed in a number of human cancers (Larkin et al., 2012; van Kester et al., 2012; Banerjee et al., 2014; Wang et al., 2014), and can promote proliferation and invasion when overexpressed in human cell lines (Banerjee et al., 2014).