As mentioned, elevated serum RBP4 levels correlate roughly with insulin resistance [79, 80] and several parameters of metabolic syndromes in humans, including body mass index, intra-abdominal fat mass, systolic blood pressure, serum triglycerides, and decreased high-density lipoproteins, even in large epidemiological studies [67, 81]. This evidence concerns the gene RBP4 and Insulin resistance.