Six weeks after injecting the low dose of streptozotocin, HFD-fed rats (n = 40) showed hyperglycemia with average blood glucose level over 16.7 mmol/L, polyuria with 1.5-fold increased urine volume, and albuminuria with urinary albumin excretion rate higher than 30 mg/24 h. The gene discussed is ALB; the disease is Hyperglycemia.