Furthermore, rather than disruption with growth factor receptors, the 5′-O-tritylthymidine (called M13) compound blocks the formation of the FAK/Mdm-2 complex; subsequently, it activates p53 and caspase-8, leading to increase detachment and apoptosis in breast and colon cancers [148]. Here, TP53 is linked to malignant colon neoplasm.