It was found that only dual inhibition of p110α and p110β was sufficient to induce tumor regression of BT474 and MCF7 xenografts and prevent partial restoration of PI(3,4,5)P3 and phospho-Akt in HER2-amplified cell lines (Costa et al., 2015; Schwartz et al., 2015). This evidence concerns the gene AKT1 and neoplasm.