Despite its central role in ribosome biogenesis, recent studies in lymphoma and leukemic cells have shown that inhibition of mTOR accounts for only part of the effect on rRNA synthesis observed during Akt inhibition, suggesting that Akt-mediated regulation of ribosome biogenesis occurs through mTOR-dependent and -independent pathways (Chan et al., 2011; Nguyen and Mitchell, 2013). Here, AKT1 is linked to lymphoma.