However, no association with breast cancer risk was detected in a subsequent large case–control study (Hilbers et al. 2012) and another study by Golmard et al. (Golmard et al. 2013) reports no pathogenic XRCC2 mutations among early-onset or familial breast cancer patients (Golmard et al. 2013). This evidence concerns the gene XRCC2 and breast cancer.