FLT3-ITD has been found to cause increased levels of ROS within murine Ba/F3 or 32D cells expressing FlT3-ITD as well as MOLM-14 and MV-4-11 human AML cell lines which carry FLT3-ITD mutations [27], suggesting that ROS are important in regulating FLT3 mutated AML. Here, FLT3 is linked to acute myeloid leukemia.