MSH2 and Lynch syndrome: It is well known that some deleterious genetic/genomic variations can be detected by means of consequent methylation changes: for example, FRAX triplet-repeat expansions cause promoter methylation and inactivation of the FRAX gene and Fragile X mental retardation [26], deletions and rearrangements of the IGF2 enhancer attenuate IGF2 expression with co-ordinate hypomethylation of promoter sequences [27] and genetic rearrangements in Lynch syndrome are detectable as epigenetic inactivation of MSH2 [28].