Data collected from our lab and by others seems to indicate that acid can turn on anabolic processes in tumor cells, due to energy efficiency with elevated protein expression for nutrient sensor GβL (G protein, beta protein subunit-like), a component of mTOR (mammalian target of rapamycin), PI3K/Akt signaling, and its downstream eIF4E tumor promoting target [53]. This evidence concerns the gene EIF4E and neoplasm.