Aging, longevity, cancer. PSMD13-SIRT3 haplotype pools are significantly different between centenarians and younger people (Bellizzi et al., 2007). Plays role in stem cells aging and stress response (Brown et al., 2013). SIRT3 can be a tumor promoter or tumor suppressor, depending on context (Alhazzazi et al., 2011). Here, SIRT3 is linked to cancer.