The correlation between the neutrophil chemokine CXCL2 and free DNA levels in CF airway fluids could, on one hand, reflect increased CXCL2-mediated neutrophil chemotaxis or could also, on the other hand, involve CXCL2 itself as potential trigger for DNA release in neutrophils. The gene discussed is CXCL2; the disease is cystic fibrosis.