Also consistent with the data obtained from human CF lung disease samples, the extent of free DNA in murine CF airway fluids correlated positively with the levels of the CXCR2 ligand CXCL2 (Figure 3(c)) and with pulmonary obstruction parameters (FEV100) (Figure 3(d)), whereas no correlation was found between free DNA and levels of CXCL1 or parameters of pulmonary restriction parameters (data not shown). Here, CXCR2 is linked to cystic fibrosis.