The genes Fam65b and Il1r1 were methylated preferentially in the non-tumor liver tissue, whereas the genes Synpo and Tspan9 were methylated preferentially in tumors; the gene Srd5a2 in each half of the tested tumors was preferentially methylated in either the non-tumor tissue or in tumors (Supplementary Figure 8). The gene discussed is SRD5A2; the disease is neoplasm.