CCND1 and breast carcinoma: Meanwhile, the high expression of cytoplasmic and/or nuclear β-catenin was found to be closely correlated with breast cancer prognosis [10], and nuclear β-catenin could interact with the lymphocyte enhancer factor/T cell factor family of transcription factors (LEF/TCF) to activate multiple cancer-related molecules, including c-Myc, cyclin D1, metalloproteinases and c-Met, etc. [11–13].