GPT and acute liver failure: Common dengue-induced laboratory changes include thrombocytopenia, leukopenia, atypical lymphocytes, immature neutrophils, raised hematocrit (Hct) and liver enzymes, mild increases in prothrombin time (PT) and activated partial thromboplastin time (aPTT), and increased fibrinolysis.14,15 Alanine transaminase (ALT)/AST increase tend to be mild to moderate (2.5–5 × upper limit of normal [ULN]), but acute liver failure with severe bleeding may occur.5,12,16,17