Integrated analysis of whole genome sequences, RNA sequences and CN changes produced five major findings: (i) frequent mutations and LOH in TP53, (2) PRIM2 loss as a frequent genetic alteration, (iii) frequent HR defects and genome-wide CNA ,(iv) clustering of structural variants in genome, and (v) polyploidy in certain low stage HGS ovarian cancers, . The gene discussed is PRIM2; the disease is ovarian cancer.