RB1 and carcinoma: Interestingly, this carcinoma also had no mutations in the high frequency driver genes found by TCGA, namely, NF1, CDK12, FAT3, GAGRA6, BRCA1 and RB1. It did, however, have a somatic CHEK2 mutation, which might well account for the genomic instability as manifested by the relatively high HRD score.