Furthermore, similar to our observations in malignant B cells 24, SLE B cells also displayed a remarkable degree of internalization of anti‐CD22 mAb, greater than that seen with RTX, whereas the other mAb (anti‐CD19, anti‐CD38, and GA101Gly) were internalized to a lesser degree. The gene discussed is CD19; the disease is systemic lupus erythematosus.