INS and type 1 diabetes mellitus: In concert with this hypothesis, our data demonstrate that relatively low plasma concentrations of insulin (∼10 μU ml−1), which are insufficient to maintain euglycemia in an insulinopenic rat model of T1D, are sufficient to suppress lipolysis in the presence of hypercorticosteronemia and offer an explanation as to the absence of an effect of adrenalectomy on glycaemia in these previous studies15, 16.