ZFX and tongue squamous cell carcinoma: Furthermore, ZFX expression in human tongue squamous cell carcinoma cell line Tca-8113 was inhibited efficiently by lentiviral-based small interference RNA (siRNA) strategy, and the impact of ZFX knockdown on cell proliferation, colony formation, cell cycle, and cell survival was investigated extensively, confirming the pathological role of ZFX for tongue SCC development and progression.