A multiple linear regression model showed a positive and significant relationship between changes in TG levels and changes in IgM concentration in males, after adjustment for potential confounding factors including age, baseline BMI, smoking status, drinking status, and family history of CVD, hypertension, hyperlipidemia, and diabetes (P = 0.04, standard β coefficient = 0.882) (Table 4). Here, CD40LG is linked to hyperlipidemia.