NKX3-1 and B-cell chronic lymphocytic leukemia: Luciferase expression driven by the 3’-UTRs of retinoblastoma binding protein 4 (RBBP4), histone deacetylase 9 (HDAC9), B-cell CLL/lymphoma 7A (BCL7A) and NK3 homeobox 1 (NKX3-1) were instead not significantly repressed demonstrating that miR-27a is not directly involved in the modulation of these putative targets (Fig 5A).