The amino-terminal domain of TyrRS (1 nM) has been reported to induce PMN migration [27], and human myelin basic protein (10–30 μg/ml) has been reported to induce a dose-dependent release of interferon-γ, TNF-α and IL-10 from the mononuclear cells of patients with multiple sclerosis [28]. This evidence concerns the gene TNF and multiple sclerosis.