MBTPS1 and neoplasm: Interestingly, administration of anti-S1P mAb alone (Arm 4) was not accompanied with a statistical reduction of primary tumor volume (mean = 724 mm3) as compared to IgG-treated control animal (Arm 1, mean = 1010 mm3) and the combination of S1P mAb with docetaxel administered at the same time (Arm 3, mean = 373 mm3) did not significantly sensitize to docetaxel alone (Arm 5) (Figure 6B and 6C).