In the first therapeutic approach, tumor-bearing mice were treated with anti-S1P mAb (50 mg/kg every other day) for a 5-day oxygenation window prior to 5 mg/kg docetaxel (Arm 2) or with a classical combination of anti-S1P mAb and docetaxel administered at the same time (Arm 3). The gene discussed is MBTPS1; the disease is neoplasm.