Our study found that the Bcl-2/Bax or Bcl-2/Bak ratios were downregulated in QGY7701 and SMMC7721 cells but were upregulated in HL7702 cells by the DHM and NDP combination (Fig 3-B and 3-C).These results indicated that DHM could promote NDP-induced hepatoma cells apoptosis via activation of the p53/Bcl-2 pathways and relieve the NDP induced damage by maintaining the Bcl-2/Bax or Bcl-2/Bak balance in normal liver cells. The gene discussed is BAK1; the disease is hepatocellular carcinoma.