Remarkably, WDR12 overexpression consistently increased BOP1 in normal adult rat hearts (P<0.05)(Fig 9A), post-infarction (P<0.05)(Fig 9C), in Ang II-induced hypertension (P<0.05)(Fig 9E) and in vitro in neonatal rat cardiomyocytes (p = 0.061)(Fig 9G and Fig 10A and 10B) and in cardiac fibroblasts (Fig 11A and Fig 12A and 12B). Here, AGT is linked to hypertensive disorder.