As shown in Table 2, multivariate analysis, adjusted by stage, pointed out the combination of SIRT1 and SIRT2 as an independent prognostic factor for poor RFS (P = 0.002; HR = 2.698; 95%CI = 1.457–4.996) and OS (P = 0.022; HR = 2.193; 95%CI = 1.118–4.300) in NSCLC. This evidence concerns the gene SIRT2 and non-small cell lung carcinoma.