Furthermore, skin biopsy tissue from patients diagnosed with Sézary syndrome, a subtype of CTCL, also revealed an increase in lymph-angiogenesis as measured by an increased staining for podoplanin (PDPN), lymphatic vessel hyaluronan receptor-1 (LYVE-1), VEGF-C, and VEGF-R3 [18]. This evidence concerns the gene VEGFC and primary cutaneous T-cell non-Hodgkin lymphoma.