To address why malignant T cells spontaneously produce LTα, we focused on the JAK3/STAT3 pathway because this cell signal pathway promotes expression of several cytokines (IL-5, IL-10, IL-13, IL-17 and IL-17F) in CTCL cells [6-10]. The gene discussed is JAK3; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.