Since lymphocytes with malignant cell morphology express VEGF-A [12], VEGF-C [51], IL-6 [10] and LTα (as shown here) in situ in CTCL skin lesions, and all of these factors are well established drivers of tumor associated (lymph)angiogenesis, our data suggest that malignant T cells orchestrate neovasculization in CTCL and, thus, contribute to the disease progression. Here, VEGFC is linked to neoplasm.