In another phase Ib trial in 113 patients with advanced solid tumors, co-treatment with trametinib and PI3K inhibitor buparlisib showed promising antitumor activity for patients with KRAS-mutant ovarian cancer, but long-term tolerability of the combination was challenging due to frequent dose interruptions and reductions for toxicity [43]. The gene discussed is KRAS; the disease is ovarian carcinoma.