TIMP1 and neoplasm: These are considered tumour suppressive [25, 26], expressing a number of tumour suppressor proteins e.g. maspin and ERβ, structural ECM proteins e.g. fibronectin, proteinase inhibitors e.g. tissue inhibitor of metalloproteinase-1 (TIMP1) and angiogenic inhibitors e.g. thrombospondin-1 [25, 27, 28].