Interestingly, we found although RKIP overexpression increased RKIP-binding Stat3, the phosphorylated level of RKIP-binding Stat3 was decreased in NPC cells, suggesting that RKIP inhibited Stat3 activity by interacting with Stat3 and then blocking its phosphorylation. The gene discussed is STAT3; the disease is nasopharyngeal carcinoma.