We found that exogenous expression of RKIP in 5-8F cells not only increased RKIP-interacting Stat3, but also decreased phospho-Stat3 level compared with control cells, indicating that RKIP inhibited Stat3 activation also by interacting with Stat3 in NPC cells (Figure 4D). The gene discussed is STAT3; the disease is nasopharyngeal carcinoma.