To explore the role of RKIP in NPC metastasis in vivo, we tested the effect of RKIP in a xenograft metastasis model in which RKIP knockdown 6-10B cells, RKIP overexpression 5-8F cells, and their corresponding control cells were used to generate pulmonary metastases in nude mice. Here, PEBP1 is linked to nasopharyngeal carcinoma.