We found that the number of cells expressing nuclear phospho-Stat3 is markedly increased in RKIP knockdown 6-10B cells, whereas obviously decreased in RKIP overexpression 5-8F cells compared with their corresponding control cells (Figure 4B), indicating that RKIP inhibited Stat3 nuclear translocation in NPC cells. The gene discussed is PEBP1; the disease is nasopharyngeal carcinoma.