Radical resection is the major treatment for invasive bladder cancer, but surgical mortality may be as high as 34%[19].Bladder cancer patients tend to be older, with multiple medical comorbidities, and many are not able to tolerate surgical resections[20].Research is increasingly focused on the development of new chemotherapy drugs and techniques of administration[21].Considering this goal, we performed an animal study by establishing a BALB/c-nu mouse model of invasive bladder carcinoma and treating it through internal iliac arterial infusion of albumin-bound As2O3. The gene discussed is ALB; the disease is urinary bladder carcinoma.