While some proteins (shown in red in Fig 1) such as CREBBP, progesterone receptor, CD56, caspase 7, caspase 1, and PDGFR-β were more highly expressed in BC tissue than in normal mucosa, other proteins (shown in green in Fig 1), including caldesmon, desmin, myeloperoxidase, and CD81, had lower expression in BC tissue. Here, DES is linked to breast cancer.