In contrast, the cholangiocytes from primary sclerosing cholangitis (PSC) livers exhibited elevated phospho-EGFR, with an approximately 5-fold increase vs. normal (NL), primary biliary cirrhosis (PBC) and Hepatitis-C virus (HCV) infected livers (Fig 4A and 4B). Here, EGFR is linked to primary biliary cholangitis.