Notably, we observed that HHT-mediated degradation of p-eIF4E greatly decreases its target molecule Mcl-1, a critical regulator that promotes the survival of AML stem cell (31), implying that targeting p-eIF4E by HHT might be an ideal therapeutic approach to eliminate leukemia stem/progenitor cells of AML. The gene discussed is ACVRL1; the disease is leukemia.