MCL1 and neoplasm: However, considering the frequent adverse effects of HHT on the hematological system, gastrointestinal tract and other organs (29, 30, 33), and because HHT also inhibits other signaling molecules such as p-210Bcr-Abl (24), c-myc (22), Mcl-1 (23), we can not rule out the possibility that HHT may have additional targets that are involved in both of anti-tumor activity and cytotoxicity.