P276-00 also downregulates Mcl-1 and induces PARP cleavage in MM cell lines (Raje et al., 2009) through inhibition of CDK9-T1 and RNA pol II-dependent transcription (Manohar et al., 2011) and shows antitumor activity in a MM xenograft model. The gene discussed is MCL1; the disease is Miyoshi myopathy.