Due to their potential ability to stabilize Notch, cyclin C/CDK8/19 inhibitors may be of therapeutic benefit for the hematologic malignancies in which Notch functions as a tumor suppressor such as CML (Yin et al., 2009; Yang et al., 2013b) and CMML (Klinakis et al., 2011). Here, CDK8 is linked to neoplasm.