CDK8 phosphorylates and inhibits E2F1, an inhibitor of β-catenin function, resulting in increased activity of the Wnt/β-catenin pathway in colon cancer cells (Morris et al., 2008) and suppression of CDK8 expression in these cells inhibits proliferation (Firestein et al., 2008). This evidence concerns the gene CDK8 and malignant colon neoplasm.