Alteration of CDK-encoding genes or their partner cyclins can lead to their overexpression, amplification and translocation, e.g., cyclin D1 alterations are observed in chronic lymphocytic leukemia (CLL), B-cell acute lymphocytic leukemia (B-ALL), mantle cell lymphoma (MCL), and multiple myeloma (MM). Here, CCND1 is linked to mantle cell lymphoma.