JAK2 and acute myeloid leukemia: In vivo, TG02 induces tumor regression after oral dosing on both daily and intermittent schedules in a murine model of FLT3-ITD leukemia (MV4-11) and prolongs survival in a disseminated AML model with wt FLT3 and JAK2 expressed in HL-60 AML cell lines (Goh et al., 2012).