Nevertheless, an upregulation was observed in fumarylacetoacetate (p≤0.014), and LTC4 synthase (p≤0.014), HOXA9 (p≤0.01), and c-myb (p≤0.01) in the CD34 positive and negative fractions, in AML, in comparison with normal BM (Fig 4). This evidence concerns the gene CD34 and acute myeloid leukemia.