These findings are in line with the results of our study that proved the serum leptin level had highest amount for the ages older than 10 years (24).Musallam KM did a 10 years follow-up study on serum ferritin level in transfusion-independent patients with beta-thalassemia and concluded that the ferritin level increased after ten years for the same patients which is in line with our findings (25). This evidence concerns the gene LEP and beta thalassemia.