To date more than 200 mutations have been reported in the POLG gene (see http://tools.niehs.nih.gov/polg/) and they are correlated with a variety of mitochondrial disorders, including Alpers syndrome, progressive external ophthalmoplegia (PEO), Parkinsonism, and other encephalomyopathies associated with mtDNA mutations, deletions, and depletions (Stumpf and Copeland, 2011). The gene discussed is POLG; the disease is Parkinsonism.