Sporadic Alzheimer's disease (AD) is a progressive chronic neurodegenerative disorder (at least 97% of all cases are non-genetic) and is characterized by severe beta-amyloid (Aβ) deposition in brain (plaques) and in vessels (cerebral Aβ angiopathy, CAA), Tau pathology, cell death of cholinergic neurons, microglial activation, inflammation and cerebrovascular damage. Here, MAPT is linked to Alzheimer disease.