Recently, the Ibero-American Alzheimer Disease Genetics Group Researchers analyzed the coding region and flanking sequences of APP, PSEN1, PSEN2, MAPT, and GRN by pooled-DNA exon sequencing in 167 clinical and five autopsy-confirmed, mainly EOAD cases (Jin et al., 2012). The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.