APP and neuroblastoma: Olivieri et al. (2000) reported an increased secretion of both Aβ-40 and Aβ-42 when neuroblastoma cells were exposed to 50 μg/dL of inorganic Hg concomitant with ROS overproduction (Olivieri et al., 2000), and a study conducted in aggregating brain-cell cultures of fetal rat telencephalon showed that MeHg (non-cytotoxic concentrations/10–50 days) produced increased APP levels accompanied by ROS production and glia activation (Monnet-Tschudi et al., 2006).