PRKN and Parkinson disease: Additionally, these miRNAs were deregulated in differentiated SH-SY5Y dopaminergic neuronal cells, which was associated with altered mitochondrial function, oxidative stress and ATP depletion, as well as decreased protein levels of DJ1 (a mitochondrial peroxidase) and Parkin (an E3 ubiquitin ligase) that are associated with the familial form of PD (Miñones-Moyano et al., 2011).