Interestingly, Tg2576 mice exposed to Al (2 mg/Kg/9 months, through the diet) showed an increased expression of miRNAs (e.g., miR146a and miR125b) involved in a pro-inflammatory response similar to that observed in AD brains (Bhattacharjee et al., 2014; Zhao et al., 2014), and treatment of primary human astroglial (HAG) cells with 100 nM of Al + Fe increased the expression of NFκB-induced miR-125b and miR-146a (Pogue et al., 2011); these miRNAs are reported in AD pathology (Lukiw, 2012). This evidence concerns the gene NFKB1 and Alzheimer disease.