Likewise, treatment of Neuro-2a cells to silver NPs (AgNPs, 12.5 μg/mL/24 h) showed the deposition of Aβ plaques and an increased expression of APP, while NEP and LPR1 (or LDLR) expression and protein levels were reduced, suggesting that AgNPs can induce AD by altering the amyloidogenic pathway: Aβ synthesis, degradation or clearance (Huang et al., 2015). Here, APP is linked to Alzheimer disease.