SNCA and Parkinson disease: Additional to the neuronal loss, the main neuropathological hallmark of PD is the presence of Lewy bodies (LB) in the surviving neurons, which are eosinophilic cytoplasmic inclusions containing aggregates of protein such as α-synuclein (α-syn) (Gibb and Lees, 1988; Spillantini et al., 1998).