Regarding in vitro studies, the exposure of human (SK-N-SH) and mouse (Neuro-2a) neuroblastoma cells to silica NPs (SiNPs) (10 μg/mL/24 h) raised the intracellular content of Aβ in both cell lines, which was associated with increased APP and reduced NEP protein levels. Here, APP is linked to neuroblastoma.