It has also been reported that HOXA11 regulates MMP-2 expression [29] and transfection with siHOTTIP also decreased both HOXA11 and MMP-2 (Figure 6C and 6D), suggesting that HOTTIP regulation of HOXA10 and HOXA11 and their downstream genes contribute to the oncogenic role of HOTTIP in pancreatic cancer cell migration/invasion. Here, HOTTIP is linked to familial pancreatic carcinoma.