It has previously been reported that some HOX genes are overexpressed in pancreatic tumors and they include HOXA10, HOXB7 and HOXB2 [23–27], and transfection of Panc1 cells with siHOTTIP slightly decreased expression of HOXB7 but significantly decreased HOXA10 (>80%) and HOXB2 (>60%). This evidence concerns the gene HOXB2 and pancreatic neoplasm.