Figures 6C and 6D show that siHOTTIP decreased both HOXA10 and HOXA11 and this was paralleled by decreased expression of MMP-3 and MMP-2, demonstrating that HOTTIP regulates specific HOX genes that play a role in the migration/invasion of pancreatic cancer cells. The gene discussed is HOXA10; the disease is familial pancreatic carcinoma.