For example, both HOTTIP and HOXA13 are upregulated in HCCs and are associated with metastasis and decreased patient survival [16]; moreover, individual knockdown of HOTTIP or HOXA13 by RNA interference (RNAi) in HCC cell lines results in downregulation of HOXA13 and HOTTIP, respectively. Here, HOXA13 is linked to hepatocellular carcinoma.