Knockdown of HOTTIP by RNAi significantly decreased proliferation of Panc1, L3.6pL, Panc28, BxPC3 and MiaPaCa2 cells (Figure 1B) and overexpression of HOTTIP increased proliferation of Panc28 cells (Figure 1C), and the growth promoting effects of HOTTIP were similar to those previously reported for HOTAIR in pancreatic cancer cells [12]. Here, HOTTIP is linked to familial pancreatic carcinoma.