Downregulation of miR-143 promotes osteosarcoma cell invasion through MMP-13 upregulation [16], and silencing of miR-133a reduces the malignancy of CD133high osteosarcoma-initiating cell population through restoring the expression of multiple target genes (SGMS2, UBA2, SNX30, and ANXA2) [17]. Here, ANXA2 is linked to osteosarcoma.