The serum concentrations of ALT, AST, TB and DB in WD patients with hypersplenism were obviously higher than their normal ranges (ALT, 5–35 U/L; AST, 8–40 U/L; TB, 2–23.4 μmol/L; and DB, 0–9.8 μmol/L) (Table 4). The gene discussed is GPT; the disease is Wilson disease.