Most recently, it was demonstrated that the activation of LXRs by GW3965 (another LXR agonist) attenuated the cardiac dysfunctions of db/db mice and the redox disorder in mice with myocardial ischemia/reperfusion injury, partly through relieving the oxidative stress via regulating another key anti-oxidase gp91phox[54,55]. This evidence concerns the gene CYBB and myocardial ischemia.