An aberrant activation of oncogenic signaling pathways, including the up-regulation of the pathway activated by the epidermal growth factor (EGF) and the loss of tumor suppressor pathways, such as the down-regulation of the transforming growth factor beta 1 (TGFβ1) signaling pathway, have been characterized as hallmarks of cancer development and progression [7,8]. Here, TGFB1 is linked to neoplasm.