We observed that lupus mice had aberrant and significantly elevated levels of IL-4, IL-6, IL-7, IL-12, IL-17, IFN-α, IFN-γ, TGF-β, BAFF and APRIL compared with the control non-lupus healthy mice (* P < 0.05). This evidence concerns the gene TNFSF13B and systemic lupus erythematosus.