Concomitant up-regulation by IL-4 of the miRNAs comprised at the third exon of the CLCN5 gene suggests that they were likely produced also, rather than through transcription from their own promoters, as a consequence of being embedded within the CLCN5 primary transcript, another gene previously found up-regulated by IL-4 in CLL and NBC [12]. This evidence concerns the gene IL4 and B-cell chronic lymphocytic leukemia.