To define the set of miRNAs significantly expressed in CLL, we examined the cumulative distributions of mature miRNAs according to their signal intensity values in the arrays performed from the 8 Pre, 15 Ctrl, and 15 IL-4 CLL samples, which described an abrupt rise between the intensity values of −9 and −7, then a plateau up to −4, and a slow increase between −3 and 9 (S1 Fig). Here, IL4 is linked to B-cell chronic lymphocytic leukemia.