In contrast, the levels of cytoprotection correlated significantly with the levels of change of miR-21-5p, miR-362-5p, and miR-500a-3p (Table 3), providing additional evidence to suggest that these miRNAs could play a role in the anti-apoptotic response induced by IL-4 in CLL. This evidence concerns the gene IL4 and B-cell chronic lymphocytic leukemia.