We and others have demonstrated that upon infection or chemokine stimulation, T cells use the immune adaptor protein ADAP (adhesion and degranulation-promoting adapter protein, also known as Fyn-binding protein [Fyb] or SLP-76 associated protein of 130 kD [SLAP-130]) to increase β2 integrin activation and adhesion [15–17]. Here, FYB1 is linked to infection.